Activating HER2 Mutations in HER2 Gene Amplification Negative Breast Cancer
نویسندگان
چکیده
منابع مشابه
Activating HER2 mutations in HER2 gene amplification negative breast cancer.
UNLABELLED Data from 8 breast cancer genome-sequencing projects identified 25 patients with HER2 somatic mutations in cancers lacking HER2 gene amplification. To determine the phenotype of these mutations, we functionally characterized 13 HER2 mutations using in vitro kinase assays, protein structure analysis, cell culture, and xenograft experiments. Seven of these mutations are activating muta...
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ژورنال
عنوان ژورنال: Cancer Discovery
سال: 2012
ISSN: 2159-8274,2159-8290
DOI: 10.1158/2159-8290.cd-12-0349